- Not the drinking kind…

• Go to regedit via

  Terminal

   wine regedit

  
  Navigate to /HKEY_Local_Machine/Software/Wine/Ports and add a new string called com1.
  Set the data to the comport (I.E. /dev/ttyUSB0)
  

run the following command in terminal

sh

 sudo rm ~/.wine/dosdevices/com1 && sudo ln -s /dev/com6 ~/.wine/dosdevices/com1 

Ensure you replace com6 with what ever com port you want to use (com7, ttyUSB0 and etc)

You need to install wine-binfmt.

Also copy wine.desktop to /usr/share/applications or to $HOME/.local/share/applications/. You will find wine.desktop in /usr/share/doc/wine/examples/wine.desktop.

Sometimes Gnome (desktop interface) has some issue, simply go and restart gnome by doing the following

On the desktop, press Alt + F2. A text box will pop up, type R and press Enter Gnome will then restart and things should work again.